组内动态

祝贺宋涛博士关于Ni2P纳米颗粒负载在氮磷共掺杂生物质碳上用于含氮杂环化合物催化转化研究论文被ACS Sustainable Chemistry & Engineering 接收

发布者:  时间:2019-12-03 16:54:57  浏览:

Highly Dispersed Single Phase Ni2P Nanoparticles on N,P-codoped Porous Carbon for Efficient Synthesis of N-Heterocycles

Tao Song, Peng Ren, Zhiming Ma, Jianliang Xiao, and Yong Yang

Abstract

Aerobic oxidative cross-dehydrogenative coupling represents one of the most straightforward and atom-economic methods for construction of C-C and C-X (X = N, O, S, or P) bonds, especially when environmentally friendly air is used as the oxidant. Herein, we report the development of an inexpensive, stable and highly dispersed ultrafine Ni2P nanoparticles with narrow size distribution supported on N,P-codoped biomass-derived porous carbon. The as-prepared catalyst is highly active and stable for the synthesis of pharmaceutically important N-heterocycles, including quinazolines, quinazolinones and imidazoles, through oxidative cross-dehydrogenative coupling of a wide range of alcohols with diamines or 2-aminobenzamides using atmospheric air as the sole oxidant under mild reaction conditions. This work provides a new method to access Nheterocycles, which is operationally simple, widely applicable to various alcohols and diamines (or 2-aminobenzamides), and capable for gram-scale synthesis, highlighting it practical potential Mechanistic studies reveal that the coupling proceeds in a cascade manner, with atmospheric air as hydrogen acceptor that significantly boosts the overall reaction efficiency.

中国科学院青岛生物能源与过程研究所

通讯地址:山东省青岛市崂山区松岭路189号